The Center is organized into the following sections:

Direction and Planning

• Scientific Board
• Scientific Director

Management and Coordination

• General Manager
• Operating Manager
• Managing Committee

Research and Development

• Research Programs and Principal Investigators
  
• Technical/Office Administration
  
• Administrative staff, technicians, etc.

The National Cancer Institute Fondazione G. Pascale of Naples I.R.C.C.S. (Scientific Hospitalization and Treatment Institute), under the direction of CROM’s General Manager, oversees the organization and management of the Center; the Campania Regional Government is responsible for financing and overseeing CROM’s activities; the Avellino Provincial Council ensures and oversees the proper maintenance and functioning of the Center. The Principal Investigators are responsible for independently carrying out their research programs at CROM.